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Saturday, 24 March 2012

This Is Dangerous !

Fatal  Familial  Insomnia (FFI)


What  is  fatal  familial  insomnia(FFI) ?


Fatal familial insomnia is a very rare autosomal dominant inherited prion disease of the brain . It is almost caused by a mutation to the protein. Fatal familial insomnia has no known cure & involves progressively worsening insomnia .This leads to hallucinations, delirium and confusional states .The average survival span for patients diagnosed with FFI after the onset of symptoms is 18 months. The mutated protein has been found in just 40 families worldwide,affecting about 100 people.


If only one parent has gene,the offspring have a 50% chance of inheriting and developing the disease. The first recorded victim was an italian man ,deceased in venice in the year 1765.


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Death usually occurs between 7 and 36 months from onset.

The disease has 4 stages :
  • Insomnia,resulting in panic attacks,phobia & paranoia.
  • Hallucination & panic attacks become noticeable.
  • Inability to sleep & rapid loss ofweight.
  • Dementia- patient become unresponsive or mute over the course of 6  months.
There is no cure or treatment for fatal familial insomnia & gene therapy is unsuccessful . Sleeping pills and barbiturates do not help but they make FFI worst and speed up the disease.



The information is from wikipedia.